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Authors: Тимофеев, С. А.
Сендерский, И. В.
Царев, А. А.
Долгих, В. В.
Title: Молекулярные основы паразито–хозяинных отношений микроспоридий и насекомых
Other Titles: Molecular basis of host-parasite interactions between microsporidia and insects
Issue Date: 2016
Language (ISO): Russian
Pages: 164-165
Description: Microsporidia comprise a group of fungi-related obligate intracellular eukaryotic pathogens with extremely wide host range: from protists to mammals. Adaptation to intracellular parasitism drive these parasites towards significant reduction and modification of the genome and functional apparatus, which causes extreme depending on the host cell, as well as sophisticated host-parasite relationships. The main tool of the direct regulatory impact of microsporidia on the host cell apparently is the secretion of the special protein effectors capable to interfere in regulatory and signaling pathways of the host cell. In this research we analyzed two secretory proteins of locust parasite microsporidium Paranosema locustae: hexokinase and α/β-hydrolaze. We demonstrated that these molecules have a different localization in the host cells; hexokinase was accumulated in its nuclei, whereas α/β-hydrolaze has a mitochondrial location.
Appears in Collections:Современные проблемы теоретической и морской паразитологии / Contemporary problems of theoretical and marine parasitology

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